HPE Unveils New ProLiant Gen12 Servers: Advanced Security, AI Automation, and Enhanced Energy Efficiency

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Innovation in Security and Performance with the New HPE ProLiant Compute Gen12

Hewlett Packard Enterprise (HPE) has announced the launch of eight new HPE ProLiant Compute Gen12 servers, designed to deliver optimized performance, advanced security, and artificial intelligence (AI)-based automation. These servers, which will incorporate new Intel Xeon 6 processors, will be available for data centers as well as edge computing environments.

Krista Satterthwaite, Senior Vice President and General Manager of Compute at HPE, highlighted that this new generation of servers addresses the growing demands of data-intensive workloads, providing businesses and government institutions with a modern and secure platform.

“This is a modern enterprise platform designed for the hybrid world, with innovative security and control capabilities that help businesses tackle evolving threats and performance challenges that their legacy hardware can no longer handle.”
Krista Satterthwaite, SVP and GM of Compute at HPE


A New Standard in Security: Protection from Chip to Cloud

HPE has taken a significant step forward in enterprise security with an infrastructure that protects servers in all phases of their lifecycle. The new servers include HPE Integrated Lights Out (iLO) 7, featuring a dedicated security processor called Secure Enclave, which safeguards the hardware against firmware attacks and offers preparation for quantum threats.

Moreover, the HPE ProLiant Compute Gen12 servers comply with the FIPS 140-3 Level 3 cryptographic security standard, positioning them as one of the most secure solutions on the market.

Security FeatureDescription
Secure Enclave in iLO 7Built-in security processor that protects the hardware against firmware attacks.
FIPS 140-3 Level 3 CertificationMeets the highest standards of cryptographic security.
Factory-Trusted ChainEnsures hardware integrity from production to the end of its lifecycle.

Improved Automation and Efficiency with AI

The new servers include HPE Compute Ops Management, a cloud-based software platform that enables automation and management of server environments using AI.

This system enhances energy efficiency and allows businesses to predict energy consumption, set usage thresholds, and reduce carbon emissions globally.

New features include:

  • Predictive Automation with AI: Reduces downtime by up to 4.8 hours per server per year.
  • Global View of Server Status: Eases management of distributed infrastructures.
  • Integration with Third-Party Tools: Compatible with multi-vendor solutions to optimize administration.

Optimized Performance and Energy Efficiency

The HPE ProLiant Compute Gen12 servers are designed to handle demanding workloads, including artificial intelligence, data analytics, edge computing, hybrid cloud, and desktop virtualization (VDI).

Compared to legacy enterprise systems, these servers offer:

BenefitImprovement Compared to Previous Systems
Performance per Watt+41% energy efficiency
Annual Energy SavingsUp to 65% reduction in consumption
Data Center Space OptimizationOne Gen12 server equals the performance of seven Gen10 servers

William Bell, Executive Vice President of Products at phoenixNAP, noted that his company was the first to adopt these servers and that the benefits were immediate.

“Partnering with innovative hardware providers like HPE enables us to deliver optimized solutions that meet our customers’ needs. With the HPE ProLiant Compute Gen12 servers, we have improved the performance, energy efficiency, and security of our infrastructure.”
William Bell, EVP of Products at phoenixNAP


Liquid Cooling for Sustainable Data Centers

To address the growing energy demands of data centers, HPE has integrated direct liquid cooling (DLC) into one-socket and two-socket servers based on Intel. This technology is up to 3,000 times more efficient than air cooling, allowing for better thermal management and reducing environmental impact.

HPE leads in liquid cooling with:

  • Over 300 patents in DLC
  • 50 years of experience in server cooling
  • The world’s fastest supercomputers using liquid cooling (according to the TOP500 list as of November 2024)

Availability and Released Models

The first six models of the new HPE ProLiant Compute Gen12 line will be available in the first quarter of 2025, including:

ModelAvailability
HPE ProLiant Compute DL320 Gen12Q1 2025
HPE ProLiant Compute DL340 Gen12Q1 2025
HPE ProLiant Compute DL360 Gen12Q1 2025
HPE ProLiant Compute DL380 Gen12Q1 2025
HPE ProLiant Compute DL380a Gen12Q1 2025
HPE ProLiant Compute ML350 Gen12Q1 2025
HPE Synergy 480 Gen12Summer 2025
HPE ProLiant Compute DL580 Gen12Summer 2025

The servers will be available independently or through HPE GreenLake, allowing businesses to scale infrastructure on demand with pay-as-you-go models.

HPE also offers advisory, management, and financing services to facilitate the adoption of these new servers.


The HPE ProLiant Compute Gen12 servers represent a technological leap in security, energy efficiency, and AI automation. With advanced features such as protection from chip to cloud, liquid cooling, and performance optimization, this new generation of servers is designed to meet the growing demands of today’s digital world.

The combination of quantum security, energy consumption reduction, and intelligent automation makes these servers a strategic solution for businesses and data centers seeking a balance between performance, sustainability, and operational costs.

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